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Heres the good news Three new weight-loss drugs are on the horizon that could help. designed to avoid the serious side effects that have undone weight-loss pills in the past. These medications must be taken for years. Several medications can work against weight loss, slowing the rate of weight loss or. This side effect is thought to be due to the drugs affect on neurotransmitters, treatment of epilepsy and migraine headaches are linked with weight gain.